产品货号：
Z16990
中文名称：
Glypican 1抗体
英文名称：
Anti-Glypican 1 antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Glypican 1 antibody |
| 指标别名 | glypican;Glypican 1;glypican1;GPC1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IP,ELISA |
| 基因名称 | GPC1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human GPC1 recombinant protein (Position:L211-R558). |
| 实际分子量 | 65KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Glypican-1 antibody is suitable for Cancer,Immunology and Nuclear Signaling research.Glypican-1 (also known as GPC1 or FLJ38078) is a member of the glypican-related integral membrane proteoglycan family (GRIPS).This protein is a heparan sulfate proteoglycan which is composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains and are anchored to the cell surface via a covalent linkage to glycosylphosphatidlyinositol (GPI).Glypicans can modify cell signaling pathways and contribute to cellular proliferation and tissue growth.In humans,glypican-1 is over expressed in breast and brain cancers (gliomas).All glypicans contain an N-terminal signal peptide and a hydrophobic domain in their C-terminal region which is required for attachment of the GPI anchor.The amino acid sequences of the six vertebrate glypican family members vary from 17% to 63% identity.The location of 14 cysteine amino acids is conserved between the glypicans,suggesting the existence of a highly similar three-dimensional structure.Heparan sulfate glycosaminoglycan chains are attached at the 50 amino acids at the C-terminal end of the protein,near the anchor and the cell membrane.Glypican functions as coreceptor for a variety of growth factors.Glypican-1 has been shown to interact with SLIT2. |
| Uniprot ID | P35052 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P) and ICC. |
| 基因名全称 | glypican 1 |
| 蛋白名全称 | Glypican-1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 ImmunoPrecipitation (IP) 1:50 Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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